Agouti expression during the middle portion of the mouse hair growth cycle induces melanocytes to synthesize yellow instead of black pigment, generating black hairs with a yellow band. Dominant agouti alleles increase the amount of yellow pigment in the coat and are associated with pleiotropic effects including obesity, diabetes and increased tumor susceptibility. Four dominant agouti alleles (Aiapy, Aiy, Asy and Avy) were recently shown to result from insertions that cause ubiquitous expression of chimeric transcripts encoding a wild‐type agouti protein(1,2). (...) Three insertions were identified as intracisternal A‐particles, which helps explain the variable coat colors and parental imprinting effects associated with some dominat agouti alleles. (shrink)

In the 1978 volume of Process Studies, Nancy Frankenberry published an article called “The Empirical Dimension of Religious Experience” that I thought was so good that I wrote her a short fan letter about it.1 She responded by saying that she was flattered by my praise because I was a model for her younger generation. For the first time in my life I felt old. And I wasn’t yet forty. But here I am, still fully employed, presenting a long (...) fan letter at her retirement. Nice irony! I want to begin laying out some of the themes and accomplishments of her distinguished career as a model philosopher of religion by discussing her early book Religion and Radical Empiricism.2 The context in which she wrote.. (shrink)

A wide-ranging, collection focusing on the practical philosophy of Williams, with many chapters on politically relevant themes and many trying to assess the importance and influence of Williams. With contributions by Roman Altshuler, Mathieu Beirlaen, Thom Brooks, Jonathan Dancy, Jennifer Flynn, Lorenzo Greco, Chris D. Herrera, James Kellenberger, Colin Koopman, Stephen Leach, Esther Abin, Nancy Matchett, Jeff McMahan, Sarah Pawlett, Jonathan Sands-Wise, Robert Talisse, and Owen Ware.

Robert Cummings Neville1 first came to my attention when I was a senior in college. "Ah, but I was so much older then, I'm younger than that now," as Bob Dylan crooned at the time. Serious and studious, I was reading scholarly journals in the stacks one Saturday night. Among them was the journal Theological Studies, and in the March 1969 issue was the most effusive book review I had ever read. It was of Neville's very first book, God (...) the Creator: On the Transcendence and Presence of God. The Dominican reviewer was suitably impressed by the "brilliant" argument, but more than that, he was astonished to think that "Neville, at the time of publication, was twenty-eight."2 Curious about a brilliant author who was still... (shrink)

Distinguished scholars provide the first book-length consideration of the work of philosopher and theologian Robert Cummings Neville, including a response from Neville himself.

This paper attempts to show that Robert Cumming’s effort in a recent article to explain the work of Jacques Derrida to American philosophers fails to present an adequate account of Derrida’s position because Cumming does not take Derrida’s philosophical views (in this case, his critique of Heidegger) seriously enough. By returning to the Heideggerian and Derridian texts, three main points become clear: first, that Cumming fails to present an alternative interpretation of Heidegger on which to base his criticisms of Derrida’s (...) reading; second, that Cumming’s specific criticisms of Derrida often fail because he engages the issues on a relatively superficial level; and, finally, that Cumming has not proven that Derrida’s work does not present a substantial challenge to Heidegger’s position. I conclude that the task of explaining Derrida’s work to American philosophers has yet to be accomplished. (shrink)

_Distinguished scholars provide the first book-length consideration of the work of philosopher and theologian Robert Cummings Neville, including a response from Neville himself._.

Providing the most thorough coverage available in one volume, this comprehensive, broadly based collection offers a wide variety of selections in four major genres, and also includes a section on film. Each of the five sections contains a detailed critical introduction to each form, brief biographies of the authors, and a clear, concise editorial apparatus. Updated and revised throughout, the new Fourth Edition adds essays by Margaret Mead, Russell Baker, Joan Didion, Annie Dillard, and Alice Walker; fiction by Nathaniel Hawthorne, (...) Ursula K. LeGuin, Anton Chekov, James Joyce, Katherine Mansfield, F. Scott Fitzgerald, William Faulkner, Alice Walker, Louise Erdrich, Donald Barthelme, and James McPherson; poems by John Donne, Robert Browning, Walt Whitman, Edwin Arlington Robinson, e.e. cummings, Langston Hughes, W.H. Auden, Philip Levine, and Louise Gluck; and plays by August Wilson, Marsha Norman, Wendy Wasserstein, and Vaclav Havel. The chapter devoted to film examines the relation of film to literature and gives the complete screenplay for Citizen Kane plus close analysis of a scene from the film. With its innovative structure, comprehensive coverage, and insightful and stimulating presentation of all kinds of literature, this is an anthology readers will turn to again and again. (shrink)

Being Alive. I Salute You Jean-LucIn this article, we bid farewell to Jean-Luc Nancy by attempting to think being-in-life in a dialogue with him. To do so, the mediation draws on a number of his key concepts, which are brought into play around the notion of life, such as breath, meaning, death, salvation, community, singular plural being, between-body, intimacy and cum. The article aims to show that Nancy is a thinker of finitude who has always given the last (...) word to life, to community, to the meaning of being and of the world. (shrink)

Since the work of Gödel and Cohen, which showed that Hilbert's First Problem was independent of the usual assumptions of mathematics, there have been a myriad of independence results in many areas of mathematics. These results have led to the systematic study of several combinatorial principles that have proven effective at settling many of the important independent statements. Among the most prominent of these are the principles diamond and square discovered by Jensen. Simultaneously, attempts have been made to find suitable (...) natural strengthenings of ZFC, primarily by Large Cardinal or Reflection Axioms. These two directions have tension between them in that Jensen's principles, which tend to suggest a rather rigid mathematical universe, are at odds with reflection properties. A third development was the discovery by Shelah of "PCF Theory", a generalization of cardinal arithmetic that is largely determined inside ZFC. In this paper we consider interactions between these three theories in the context of singular cardinals, focusing on the various implications between square and scales, and on consistency results between relatively strong forms of square and stationary set reflection. (shrink)

We present a survey of combinatorial set theory relevant to the study of singular cardinals and their successors. The topics covered include diamonds, squares, club guessing, forcing axioms, and PCF theory.

In Aristotle’s account of change, lacking a form is called privation (Physics I.7 191a14). For example, someone takes on the form of being musical only from previously having the privation of being unmusical. However, he also states that “shape and nature are spoken of in two ways, for the privation too is in a way form” (Physics II.1 193b19). I will demonstrate that these seemingly contradictory statements are not actually in tension. Since all perceptible matter must be enformed, we would (...) have trouble discussing things that have yet to undergo generation, like menstrual fluid, and things that have undergone corruption, like corpses, if we did not cite the privation as a sort of form. I will argue that, given his commitment to hylomorphism, Aristotle is committed to privation being a form in a qualified sense. It cannot be a form in an unqualified sense because privation often spoils the matter such that it can no longer be reformed. The fact of the matter is we cannot draw a bright line between privation and form because the two are contraries and can be said to hold to different degrees at different points on a spectrum. (shrink)

Bioethics needs an expanded moral vision. It is now time for bioethics to take full account of the problems of health disparities and structural injustice that are made newly urgent by the COVID-19 pandemic and the effects of climate change. Nancy M. P. King, Gail E. Henderson, and Larry R. Churchill make the case for a more social understanding and application of justice, a deeper humility in assessing expertise in bioethics consulting, a broader and more relevant research agenda, and (...) greater appreciation of the profound health implications of global warming. (shrink)

Combining techniques of the first author and Shelah with ideas of Magidor, we show how to get a model in which, for fixed but arbitrary finite n, the first n strongly compact cardinals κ 1 ,..., κ n are so that κ i for i = 1,..., n is both the i th measurable cardinal and κ + i supercompact. This generalizes an unpublished theorem of Magidor and answers a question of Apter and Shelah.

Many children and adults experience significant breakdown in the use of language. The resulting pragmatic disorders present a considerable barrier to effective communication. This book is the first critical examination of the current state of our knowledge of pragmatic disorders and provides a comprehensive overview of the main concepts and theories in pragmatics. It examines the full range of pragmatic disorders that occur in children and adults and discusses how they are assessed and treated by clinicians. Louise Cummings attempts (...) to integrate the fields of pragmatics, language pathology and cognitive science by examining the ways in which pragmatics can make a useful contribution to debates about cognitive theories of autism. The reader is encouraged to think in a critical fashion about how clinicians, experimentalists and theorists deal with pragmatic issues. (shrink)

Opponents of ceteris paribus laws are apt to complain that the laws are vague and untestable. Indeed, claims to this effect are made by Earman, Roberts and Smith in this volume. I argue that these kinds of claims rely on too narrow a view about what kinds of concepts we can and do regularly use in successful sciences and on too optimistic a view about the extent of application of even our most successful non-ceteris paribus laws. When it comes to (...) testing, we test ceteris paribus laws in exactly the same way that we test laws without the ceteris paribus antecedent. But at least when the ceteris paribus antecedent is there we have an explicit acknowledgment of important procedures we must take in the design of the experiments — i.e., procedures to control for “all interferences” even those we cannot identify under the concepts of any known theory. (shrink)

Public health communication makes extensive use of a linguistic formulation that will be called the “no evidence” statement. This is a written or spoken statement of the form “There is no evidence that P” where P stands for a proposition that typically describes a human health risk. Danger lurks in these expressions for the hearer or reader who is not logically perspicacious, as arguments that use them are only warranted under certain conditions. The extent to which members of the public (...) are able to determine what those conditions are will be considered by examining data obtained from 879 subjects. The role of “no evidence” statements as cognitive heuristics in public health reasoning is considered. (shrink)

In this paper, I shall defend Russell's view that Mont Blanc, with all of its snow elds, is a component part" or constituent of what is actually asserted when one utters Mont Blanc is more than 4000 meters high," and of what one believes, when one believes that Mont Blanc is 4000 meters high. I also claim, however, that a proposition that does not have Mont Blanc as a constituent plays an important role in the assertion and the belief that (...) Mont Blanc is more than 4000 meters high. Taken somewhat out of context, the quotes from Frege and Russell express insights that pull in di erent directions in the contemporary philosophy of language. Behind Frege's remark is the insight that reference is not direct but mediated. When we think and talk about things, our thoughts and words are not in direct contact with the things thought about and talked about. The meanings of our words, and the cognitive roles of our ideas, do not in and of themselves determine their reference. They get at objects via some aspects of.. (shrink)

Institutional review boards and investigators are used to talking about risks of harm. Both low risks of great harm and high risks of small harm must be disclosed to prospective subjects and should be explained and categorized in ways that help potential subjects to understand and weigh them appropriately. Everyone on an IRB has probably spent time at meetings arguing over whether a three-page bulleted list of risk description is helpful or overkill for prospective subjects. Yet only a small fraction (...) of all the time and attention lavished on risk disclosure has been devoted to discussing whether and when potential benefit to subjects can reasonably be claimed and, if so, how it should be described in the consent form and process.Traditionally, IRBs and regulators have worked to ensure that clear lines can be drawn between research that, by definition, carries no potential for direct benefit — because it uses healthy volunteers or because it is not foreseeably focused on the development of treatments — and research that does have the development of effective treatments as its goal. (shrink)

This article challenges the idea that it is possible to produce a theory of context. Such a theory, it is argued, is unintelligible by virtue of the fact that it leaves us with no prior rational concepts with which to make sense of or understand a theory of context. This argument is developed in relation to the treatment of context in clinical pragmatics. The article examines how clinicians and experimentalists examine pragmatic disorders in children and adults. This examination, it is (...) contended, ends up distorting the notion of context that is integral to utterance (pragmatic) interpretation. It is argued that this distortion arises when we mistakenly believe that we can assume a metaphysical standpoint in our deliberations about context. (shrink)

The activities of the life sciences are essential to provide solutions for the future, for both individuals and society. Society has demanded growing accountability from the scientific community as implications of life science research rise in influence and there are concerns about the credibility, integrity and motives of science. While the scientific community has responded to concerns about its integrity in part by initiating training in research integrity and the responsible conduct of research, this approach is minimal. The scientific community (...) justifies itself by appealing to the ethos of science, claiming academic freedom, self-direction, and self-regulation, but no comprehensive codification of this foundational ethos has been forthcoming. A review of the professional norms of science and a prototype code of ethics for the life sciences provide a framework to spur discussions within the scientific community to define scientific professionalism. A formalization of implicit principles can provide guidance for recognizing divergence from the norms, place these norms within a context that would enhance education of trainees, and provide a framework for discussing externally and internally applied pressures that are influencing the practice of science. The prototype code articulates the goal for life sciences research and the responsibilities associated with the freedom of exploration, the principles for the practice of science, and the virtues of the scientists themselves. The time is ripe for scientific communities to reinvigorate professionalism and define the basis of their social contract. Codifying the basis of the social contract between science and society will sustain public trust in the scientific enterprise. (shrink)

According to the United Network for Organ Sharing http://www.unos.org), over 4,100 Americans are currently candidates for heart transplants, meaning that they desperately need them, they satisfy the criteria for "medical utility" (i.e., a transplant will probably keep them alive), and they have adequate insurance or other funding to cover their cost. Unfortunately the supply of hearts in this country doesn't even come close to meeting the demand: only 2,202 heart transplants were performed last year. Thus, every day some Americans die (...) waiting for new hearts. (shrink)

The Accreditation Board of Engineering and Technology (ABET) has declared that to achieve accredited status, “engineering programs must demonstrate that their graduates have an understanding of professional and ethical responsibility.” Many engineering professors struggle to integrate this required ethics instruction in technical classes and projects because of the lack of a formalized ethics-in-design approach. However, one methodology developed in human-computer interaction research, the Value-Sensitive Design approach, can serve as an engineering education tool which bridges the gap between design and ethics (...) for many engineering disciplines. The three major components of Value-Sensitive Design, conceptual, technical, and empirical, exemplified through a case study which focuses on the development of a command and control supervisory interface for a military cruise missile. (shrink)

In a famous paper in Noûs in 1979, John Perry points out that action depends on indexical beliefs. In addition to “third-person” information about her environment, an agent need “first-person” information about where, when and who she is. This conclusion is widely interpreted as a reason for thinking that tensed claims cannot be translated without loss into untensed language; but not as a reason for realism about tensed facts. In another famous paper in the same volume of Noûs, (...) class='Hi'>Nancy Cartwright argues that action requires that agents represent their world in causal terms, rather than merely probabilistic terms: for, Cartwright argues, there’s a distinction between effective and ineffective strategies, that otherwise goes missing. This is widely taken as a reason for thinking that causal claims cannot be translated without loss into merely probabilistic claims; and also – in contrast to Perry’s case – widely regarded as a reason for realism about causation. In this paper I ask whether the latter conclusion is compulsory, or whether, as in Perry’s case, the need for causal beliefs might merely reflect some “situated” aspect of a decision-maker’s perspective. (shrink)

We start by studying the relationship between two invariants isolated by Shelah, the sets of good and approachable points. As part of our study of these invariants, we prove a form of “singular cardinal compactness” for Jensen's square principle. We then study the relationship between internally approachable and tight structures, which parallels to a certain extent the relationship between good and approachable points. In particular we characterise the tight structures in terms of PCF theory and use our characterisation to prove (...) some covering results for tight structures, along with some results on tightness and stationary reflection. Finally, we prove some absoluteness theorems in PCF theory, deduce a covering theorem, and apply that theorem to the study of precipitous ideals. (shrink)

There is a takeover movement fast gaining influence in development economics, a movement that demands that predictions about development outcomes be based on randomized controlled trials. The problem it takes up—of using evidence of efficacy from good studies to predict whether a policy will be effective if we implement it—is a general one, and affects us all. My discussion is the result of a long struggle to develop the right concepts to deal with the problem of warranting effectiveness predictions. Whether (...) I have it right or not, these are questions of vast social importance that philosophers of science can, and should, help answer. (shrink)

Studys the philosophy of Aristotle, Plato, Descartes, Rousseau, Kant, Hume, Locke, and Hegel and examines their underlying assumptions about women.

Pragmatic disorders pose a barrier to effective communication in a significant number of children and adults. For nearly forty years, clinical investigators have attempted to characterize these disorders. This chapter examines the state of the art in clinical pragmatics, a subdiscipline of pragmatics that studies pragmatic disorders. The findings of recent empirical research in a range of clinical populations are reviewed. They include developmental pragmatic disorders found in autistic spectrum disorders, specific language impairment, intellectual disability and the emotional and behavioural (...) disorders, as well as acquired pragmatic disorders in adults with left- or right-hemisphere damage, traumatic brain injury, schizophrenia, and the dementias. Techniques used by clinicians to assess and treat pragmatic disorders are addressed. In recent years, theoretical frameworks with a cognitive orientation have increasingly been used to explain pragmatic disorders. Two such frameworks—relevance theory and theory of mind—will be examined in this essay. (shrink)

An important consideration which runs through the adjudication process in each dimension is that of insight vs. blindness. Whether it is a question of deciding if one description is a persuasive critique of another, or which of two rivals is more adequate empirically, or which is a more plausible and convincing narrative, one is always involved in assessing how far and how much each of the accounts permits us to see. The centrality of this notion certifies the inescapably hermeneutical character (...) of social description adjudication. It precludes the possibility of a decision-procedure, but not of rationality. The alternative to a canonical method of description adjudication is not relativism but hermeneutics. ;My argument for a hermeneutical approach to social description adjudication is made largely via consideration of a series of examples. I look at a collection of rival accounts of the same portion of social reality and at the process of choosing between them. I consider the sorts of reasons and arguments that might be advanced for preferring one to another and I evaluate them. The descriptions I look at are accounts of the French Revolution of 1848 and they include Karl Marx's Eighteenth Brumaire of Louis-Bonaparte, Victor Hugo's Napoleon the Little, Gustave Flaubert's Sentimental Education and the works of two recent twentieth century social historians. ;I show that these descriptions are complexes of at least three analytically distinct components: critical, empirical and narrative. I show, therefore, that the choice between them can be made from at least three corresponding standpoints. But I also argue that these three dimensions are not independent of one another; each, rather, presupposes the others and none is foundational with respect to the others. Adjudicating between competing social descriptions, then, turns out to be a complex non-canonical process of weighing the relative merits within each dimension. ;I counterpose to the decision-procedure model of social description adjudication a hermeneutical model. I show that good and convincing reasons for preferring one social description or historical interpretation to another need not be strictly derivable from or translatable into a set of universal rules capable of being formulated independently of and in advance of the consideration of the particular case. I show, rather, that rational adjudication between competing social descriptions consists in creative rule-transcending judgment akin to Aristotelian phronesis or Kantian reflective judgment. ;It is often presupposed that choices between competing theories, interpretations, actions or whatever qualify as rational just in case they result from the application of some decision-procedure. I take issue with this assumption when what is at stake is choosing between competing descriptions of social reality. I argue that there is not and cannot be a decision-procedure governing such choices, but that such choices may nonetheless be rational and intersubjectively defensible. (shrink)

Jech and Shelah in J Symb Log, 55, 822–830 (1990) studied full reflection below ${\aleph_\omega}$ , and produced a model in which the extent of full reflection is maximal in a certain sense. We produce a model in which full reflection is maximised in a different direction.

Medical error is a leading problem of health care in the United States. Each year, more patients die as a result of medical mistakes than are killed by motor vehicle accidents, breast cancer, or AIDS. While most government and regulatory efforts are directed toward reducing and preventing errors, the actions that should follow the injury or death of a patient are still hotly debated. According to Nancy Berlinger, conversations on patient safety are missing several important components: religious voices, traditions, (...) and models. In After Harm, Berlinger draws on sources in theology, ethics, religion, and culture to create a practical and comprehensive approach to addressing the needs of patients, families, and clinicians affected by medical error. She emphasizes the importance of acknowledging fallibility, telling the truth, confronting feelings of guilt and shame, and providing just compensation. After Harm adds important human dimensions to an issue that has profound consequences for patients and health care providers. (shrink)

In this paper I argue that a narrow view of justice dominates the bioethics literature. I urge a broader view. As bioethicists, we often conceive of justice using a medical model. This model focuses attention at a particular point in time, namely, when someone who is already sick seeks access to scarce or expensive services. A medical model asks how we can fairly distribute those services. The broader view I endorse requires looking upstream, and asking how disease and suffering came (...) about. In contrast to a medical model, a social model of justice considers how social determinants affect the health of a population. For example, social factors such as access to clean drinking water, education, safe workplaces, and police protection, profoundly affect risk for disease and early death. I examine one important social determinant of health, health care coverage, to show the limits of a medical model and the merits of a broader view. (shrink)

' this volume will make a significant contribution to a more adequate understanding of the 'nature of scientific knowledge and inquiry' ' ISIS Vol.79,No.1,1988.

This paper proposes an essentially theoretical reflection on initial training, a reflection based on four fundamental concepts: professional development, professional identity, well-being and strengths of character. More specifically, recognizing the complexity of the teaching profession, the authors argue that the teacher training in Quebec gives too little room for self-reflection. According to them, this reflection should be based on a search for meaning in terms of a vision of well-being. Positive psychology research on strengths of character may provide useful avenues (...) for rethinking teacher education. (shrink)